Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor γ Agonists/Soluble Epoxide Hydrolase Inhibitors.
#Roze siah part 291 driver#
NUAK family kinase 2 is a novel therapeutic target for prostate cancer.įu W, Zhao MT, Driver LM, Schirmer AU, Yin Q, You S, Freedland SJ, DiGiovanni J, Drewry DH, Macias E Rota IA, Handel AE, Maio S, Klein F, Dhalla F, Deadman ME, Cheuk S, Newman JA, Michaels YS, Zuklys S, Prevot N, Hublitz P, Charles PD, Gkazi AS, Adamopoulou E, Qasim W, Davies EG, Hanson I, Pagnamenta AT, Camps C, Dreau HM, White A, James K, Fischer R, Gileadi O, Taylor JC, Fulga T, Lagerholm BC, Anderson G, Sezgin E, Holländer GA Zhou M, Ehsan F, Gan L, Dong A, Li Y, Liu K, Min JĮxploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function.įOXN1 forms higher-order nuclear condensates displaced by mutations causing immunodeficiency. Structural basis for the recognition of the S2, S5-phosphorylated RNA polymerase II CTD by the mRNA anti-terminator protein hSCAF4. Piticchio SG, Martínez-Cartró M, Scaffidi S, Rachman M, Rodriguez-Arevalo S, Sanchez-Arfelis A, Escolano C, Picaud S, Krojer T, Filippakopoulos P, von Delft F, Galdeano C, Barril X Robers MB, Wilkinson JM, Vasta JD, Berger LM, Berger BT, Knapp Sĭiscovery of Novel BRD4 Ligand Scaffolds by Automated Navigation of the Fragment Chemical Space. Single tracer-based protocol for broad-spectrum kinase profiling in live cells with NanoBRET.
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